Diclofenac
Indications :-
Acute musculo-skeletal pain; arthritis; gout; spondylitis; migraine; post-operative pain.
Availability :-
TABLETS 25 and 50 mg Plain; 75 and 100 mg SR; CAPSULES 100 mg, 100 mg CR; INJECTION 3 ml ampoule (25 mg/ml); EYE/EAR DROPS 0.1% w/v; SUPPOSITORIES 25, 50 and 100 mg; GEL 1% w/w.
Dose :- Oral :-
100 to 150 mg daily in 2 to 3 divided doses, (max 150 mg/day) maintenance by 50 to 100 mg in divided doses.
Intramuscular injection :-
75 mg, 2 to 3 times daily.
Adult- Apply 1% w/w gel on to affected area 3 to 4 times daily.
Instill to eye
Post-operative ocular inflammation:
Adult :- as sodium (1% w/v), 4 times daily starting 24 h after surgery for up to 28 days.
Rectal :- Post-operative pain.
Adult- 75 to 150 mg daily in divided doses (max. 150 mg/day, inclusive of diclofenac administered through other routes). Child- 6 to 12 year: 1 to 2 mg/kg/day in divided doses for max. of 4 days.
Contraindication :-
Porphyria; avoid injections containing benzyl alcohol in neonates; history of gastric ulcers, bleeding or perforation.
Additional contraindications include concomitant NSAID or anticoagulant use (including low-dose heparin); history of haemorrhagic diathesis; history of confirmed or suspected cerebrovascular bleeding; operations with high risk of haemorrhage; history of asthma; moderate or severe renal impairment; hypovolaemia; dehydration.
Precautions :-
NSAIDs should be used with caution in the elderly (risk of serious side-effects and fatalities); interactions (Appendices 6a, 6c, 6d); pregnancy (Appendix 7c); patients with coagulation disorders; hepatic, renal and cardiac impairment; history of gastrointestinal lesions.
Adverse effects :-
Injection site reactions; transient epigastric pain, risk of thrombotic events; toxic epidermal necrolysis; Abnormality in kidney function.
Storage :-
Store protected from light.
